![]() ![]() The overall effect of NPWT on pain is uncertain (very low‐certainty evidence from seven trials (2218 participants) which reported disparate measures of pain) but moderate‐certainty evidence suggests there is probably little difference between the groups in pain after three or six months following surgery for lower limb fracture (one trial, 1549 participants). The effect of NPWT on occurrence of haematoma or skin blisters is uncertain (very low‐certainty evidence) for haematoma, the RR was 0.67 (95% CI 0.28 to 1.59 I 2 = 0% nine trials 1202 participants) and for blisters the RR was 2.64 (95% CI 0.65 to 10.68 I 2 = 69% seven trials 796 participants). For reoperation, the RR was 1.04 (95% CI 0.78 to 1.41 I 2 = 13% 12 trials 3523 participants) for seroma, the RR was 0.72 (95% CI 0.50 to 1.05 I 2 = 0% seven trials 729 participants). There is low‐certainty evidence showing no clear difference between NPWT and standard treatment for the outcomes of reoperation and incidence of seroma. There is low‐certainty evidence (downgraded once for risk of bias and once for imprecision) showing no clear difference in the risk of dehiscence after surgery for NPWT (5.3% of participants) compared with standard dressings (6.2% of participants) (RR 0.88, 95% CI 0.69 to 1.13 I 2 = 0%). Eighteen studies reported dehiscence 14 of these (3809 participants) were included in meta‐analysis. There is moderate‐certainty evidence (downgraded once for risk of bias) that NPWT probably results in fewer SSI (8.8% of participants) than treatment with standard dressings (13.0% of participants) after surgery RR 0.66 (95% CI 0.55 to 0.80 I 2 = 23%). Thirty‐nine studies reported SSI 31 of these (6204 participants), were included in meta‐analysis. There is low‐certainty evidence (downgraded twice for imprecision) showing no clear difference in the risk of death after surgery for people treated with NPWT (2.3%) compared with standard dressings (2.7%) (risk ratio (RR) 0.86 95% confidence interval (CI) 0.50 to 1.47 I 2 = 0%). Most studies had unclear or high risk of bias for at least one key domain.įour studies (2107 participants) reported mortality. ![]() All studies compared NPWT with standard dressings. Economic studies assessed NPWT in orthopaedic, obstetric and general surgical settings. Studies evaluated NPWT in the context of a wide range of surgeries including orthopaedic, obstetric, vascular and general procedures. In this third update, we added 15 new randomised controlled trials (RCTs) and three new economic studies, resulting in a total of 44 RCTs (7447 included participants) and five economic studies. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |